- This Request for Applications (RFA) solicits new and competing continuation applications for national Mouse Metabolic Phenotyping Centers (MMPC) for the purpose of detailed metabolic phenotyping of genetically altered mice and other mouse models potentially useful for understanding diabetes and its complications, obesity, and related metabolic diseases or conditions. Mice can be shipped to these facilities to undergo on a fee-for-service basis a range of standardized procedures to characterize metabolism, body composition, feeding behavior, activity, tissue pathology, organ function, and other physiologic, anatomic or pathological alterations.
- The MMPC program was established in 2001 with four Centers. Users are academic and non-academic diabetes and obesity researchers, from within and outside the USA, both NIH and non-NIH funded.
- Information about the current MMPCs, including a catalog of services, guidelines and policies, can be found at http://www.mmpc.org/.
- The total amount to be awarded is $4.2 million for each of 5 years.
- The NIDDK and NHLBI anticipate awarding 4-5 phenotyping Centers. A Coordinating and Bioinformatics Unit (CBU) will be shared between the MMPC and the Animal Models of Diabetic Complications Consortium (AMDCC), and will be competed through a separate RFA.
- This RFA will use the U24 Cooperative Agreement mechanism. Centers will work together as a consortium with the CBU, with substantial involvement from NIH staff.
- We expect that at least one of the successful Centers will have a strong focus on phenotyping for diabetic complications.
- For-profit and non-profit organizations are eligible, including public or private institutions, units of state and local governments, eligible agencies of the federal government, domestic or foreign institutions/organizations, and faith-based or community-based organizations.
- Any individual with the skills, knowledge, and resources necessary to execute the functions proposed for the MMPC phenotyping center is invited to work with their institution to develop an application for support. Individuals from underrepresented racial and ethnic groups as well as individuals with disabilities are always encouraged to apply for NIH programs.
- Investigating institutions may submit one MMPC Phenotyping Center application to this RFA.
- Applications must be prepared using the PHS 398 research grant application and forms (rev. 09/2004; http://grants.nih.gov/grants/funding/phs398/phs398.html).
- Telecommunications for the hearing impaired is available at: TTY 301-451-0088.
Who can apply:
City Or Township Governments
Federally Recognized Indian Tribal Governments
Independent School Districts
Native American Organization
Non-Government - General
Nonprofits Having A 501(C)(3) Status With The IRS, Other Than Institutions Of Higher Education
Nonprofits That Do Not Have A 501(C)(3) Status With The IRS, Other Than Institutions Of Higher Education
Other Private Institution/Organization
Private Institutions Of Higher Education
Private Nonprofit Institution/Organization (Includes Institutions Of Higher Education, Hospitals)
Public And State Controlled Institutions Of Higher Education
Public Housing Authorities/Indian Housing Authorities
Quasi-Public Nonprofit Institution/Organization
Small Business (Less Than 500 Employees
Special District Governments
State (Includes District Of Columbia; Includes Institutions Of Higher Education And Hospitals)
U.S. Territories And Possessions (Includes Institutions Of Higher Education, Hospitals)
Eligible functional categories:
Diabetes, Endocrinology and Metabolism Research
Heart and Vascular Diseases Research
Kidney Diseases, Urology and Hematology Research
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